The diagnostic role of signal peptide–C1r/C1s, Uegf, and Bmp1–epidermal growth factor domain-containing protein 1 in non–ST-elevation acute coronary syndrome

Abstract Objective Chest pain and/or electrocardiogram changes in non–ST elevation or suspicious chest pain and cardiac marker elevations are defined as non–ST-elevation acute coronary syndrome (NSTE-ACS). Serial electrocardiogram and marker follow-up are needed to make a diagnosis of NSTE-ACS and to eliminate noncoronary chest pain (NCCP). Signal peptide–C1r/C1s, Uegf, and Bmp1–epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the α granules of inactive platelets and secreted at a high rate during thrombosis. We believe that SCUBE1 may be a sensitive early diagnostic indicator in distinguishing coronary-induced chest pain from noncoronary-induced chest pain. Materials and methods The study included 190 patients with an initial diagnosis of acute coronary syndrome in the emergency department. Based on a definitive diagnosis, these patients were classified into 3 groups: ST-elevation myocardial infarction (STEMI), NSTE-ACS, and NCCP. Results Plasma SCUBE1 levels were significantly higher in the STEMI group when compared with those of the other groups ( P P P Conclusion High rates of SCUBE1 were found both in the STEMI and NSTE-ACS patients. Furthermore, in the study group, SCUBE1 was an adequate marker for distinguishing NSTE-ACS from NCCP.