The many faces of Guillain-Barré syndrome

1. E. Steve Roach, MD 1. Editorial Board Member, Pediatrics in Review 2. Division of Child Neurology, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH Most of us learned the basic clinical manifestations of Guillain-Barre syndrome in medical school and likely have encountered at least a few children with the condition during residency or in practice. Four January 2018 Pediatrics in Review articles focus on this immune-mediated peripheral neuropathy, emphasizing some of its less common clinical patterns that are apt to be less familiar to most physicians. In their In Brief on the topic, Chung and Deimling (1) summarize the classic manifestations of Guillain-Barre syndrome. This is an acute-onset, immune-mediated peripheral neuropathy that likely is triggered by an infection or another immune stimulus. Guillain-Barre syndrome classically presents as an acute-onset, rapidly progressive, flaccid weakness starting in the legs, associated with diminished or absent tendon reflexes. …