Prognostic relevance of LGALS3BP in human colorectal carcinoma.

Enza Piccolo,Nicola Tinari,Domenica D’Addario,Cosmo Rossi,Valentina Iacobelli,Rossana La Sorda,Rossano Lattanzio,Maurizia D’Egidio,Annalisa Di Risio,Mauro Piantelli,Pier Giorgio Natali,Stefano Iacobelli

Prognostic relevance of LGALS3BP in human colorectal carcinoma.

2015

Enza Piccolo
Nicola Tinari
Domenica D’Addario
Cosmo Rossi
Valentina Iacobelli
Rossana La Sorda
Rossano Lattanzio
Maurizia D’Egidio
Annalisa Di Risio
Mauro Piantelli
Pier Giorgio Natali
Stefano Iacobelli

Background A previous report has shown that LGALS3BP (also known as 90K or Mac-2 BP) has antitumor activity in colorectal cancer (CRC) via suppression of Wnt signalling with a novel mechanism of ISGylation-dependent ubiquitination of β-catenin. The role of LGALS3BP in CRC prognosis was investigated.

Keywords:

Immunology
Beta-catenin
Gene silencing
Colorectal cancer
Wnt signaling pathway
Cell growth
Downregulation and upregulation
HEK 293 cells
Medicine
Immunohistochemistry
Cell culture
Lower risk

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