Re-Resection And Intraoperative Radiotherapy For Malignant Gliomas Of The Brain: A History And Review Of Current Techniques

Abstract The degree of primary resection of malignant brain gliomas (MG) positively correlates with progression-free and overall survival. Indications for surgery and reoperation in MG relapse remain controversial. Surgery is not curative and should be followed by adjuvant treatment. This article reviews the literature with respect to re-resection and the various methods of intraoperative radiotherapy for MG from initial experience with high-energy linear accelerators in Japan to modern, integrated brachytherapy solutions based on solid and balloon applicators. Based on this review, the authors have begun their own research into the use of intraoperative balloon brachytherapy for recurrent MG.