Análisis de sobrevida del cancer gástrico en anillo de sello según profundidad y compromiso linfonodal

Objetivo: Comparar la sobrevida del cancer gastrico en anillo de sello (AS) con los otros tipos de adenocarcinoma (no anillo de sello (NAS)), segun el compromiso en profundidad de la pared gastrica (T) y los numeros de linfonodos comprometidos (N). Material y Metodos: Se realizo un estudio de cohorte retrospectivo, en el cual se selecciono a todos los pacientes gastrectomizados por adenocarcinoma gastrico en el Hospital Base Valdivia entre los anos 1988-2005. Se compararon los pacientes cuyo informe histopatologico concluia que el cancer gastrico era un AS (mas del 50 por ciento de sus celulas son anillo de sello) con los que no lo eran (NAS). En el analisis estadistico se utiliza el test de por ciento, Metodo de Kaplan Meier, test de Log Rank. Resultados: Total 287 casos. 60 AS y 227 NAS. No hubo diferencias estadisticamente significativas en cuanto a la profundidad tumoral entre ambos grupos. Los AS presentaron mayor compromiso linfonodal. Al comparar la sobrevida a 5 anos de los AS con los NAS por estadio (TNM), no encontramos diferencias significativas. Conclusion: A la luz de este trabajo el tipo histologico anillo de sello no parece constituir un factor de mal pronostico en el cancer gastrico. Background: Signet ring cell (SRC) carcinoma of the stomach corresponds to 3 to 39 percent of all cases of gastric cancer. It tends to be less differentiated, infiltrative and diffuse. It is not clear if it has a different prognosis than other types of gastric cancer. Aim: to compare the survival of SRC gastric carcinoma with other types of gastric cancer, considering depth of gastric wall involvement and number of infiltrated lymphnodes. Material and Methods: Retrospective review of pathology samples of all gastric cancers operated between 1988 and 2005. Survival of patients with and without SRC gastric cancer was compared. Results: A total of 287 cases were reviewed. Of these 60 had a SRC gastric cancer. No differences in gastric wall infiltration between SRC and non SRC gastric cancer was observed. SRC gastric cancer has a higher frequency of lymph node involvement. No differences in survival between SRC and non SRC gastric cancer, were observed. Conclusions: In this retrospective series of patients, no differences in survival were observed between SRC and non SRC gastric cancer.