Palladium-catalyzed ortho-selective CH bond chlorination of aromatic ketones

Abstract A palladium-catalyzed ortho -selective C H bond chlorination reaction for the preparation of 2-chloro aromatic ketones was described. Both electron-withdrawing and electron-donating groups on the aromatic rings are well tolerated under the optimized conditions. The 2-chloro aromatic ketones obtained by our method could be applied to synthesize the derivatives of 1 H -indazole or benzo[ d ]isoxazole.