Ancestralidade em Salvador - BA

Native American, Africans and Europeans are the major founder populations of Brazil and of Salvador city. Brazilian population is considered as the most heterogeneous in the world, resulting from 5 centuries of miscegenation. However, ethnic ancestral groups were not distributed equally in the different Brazilian regions. In addition, a strong bias occurred originated by more frequent unions among European men and Amerindians and Africans women. Results from IBGE 2000 show that in Salvador the percent of selfclassification afrodescending, is 79.8 %. To estimate the contribution of ancestral groups in these populations we analyzed some population specific alleles: AT3-I/D, APO, SB19.3, PV92, FYnull, LPL, CKMM, GC and CYP3A4 from 1,286 subjects of Salvador that presents large frequency differential among ancestry groups. To estimate the African origin of the subjects we also analyzed the religious connotation surnames. We identified 287 surnames in these populations. In Salvador population, the frequency of religious connotation surnames was 54. 9% and we observed an inverse relation between socioeconomic status and the presence of this type of surname. These data were confirmed for a major African genomic ancestry (53. 1%) between individuals that present religious connotation surname. The miscegenation of Salvador was confirmed by the frequencies differences in this population with the ancestry, such as the population admixture esteemed, with African contribution of 49.2%; 36.3% European and 14.5% Amerindian and also by heterozygosis mediam analyses (0,397) and populational structure. F statistic (0,005) was calculated and showed differences between regions in the city, but in little proportions, confirming the admixture estimated in these regions. When we compared IBGE- 2000 African contribution esteemed, by autodenomination, with the surnames and molecular data of this work we concluded that autodenomination is an inaccurate criterion to evaluate the parental contribution into this population. This kind of work can support association studies among health factors with ancestry heterogeneity to improve and/or to implement public health programs that consider the parental composition of this population.