Subcellular Biochemical and Pathological Correlates in Experimental Models of Hepatotoxicity

Side effects of drugs often result from impairment of liver function or structural damage to hepatocytes. To evaluate toxic interactions, the assessment of adverse changes manifesting in basic parameters of hepatic activities is important. Clinical observations in humans and experimental investigations in animals have frequently revealed impairment of liver function. This chapter will survey the relevant studies and update the approaches concerning the intrinsic relationship which exists between structural and support tissue or cell components and functional, metabolic or enzymatic parameters of hepatocytes responding to toxic drug effects.