A green approach for the regio- and stereo-selective syntheses of (Z)-3-methyleneisoindoline-1-ones in aqueous medium
2013
Abstract A high yielding novel methodology was developed for the regio- and stereo-selective syntheses of ( Z )-3-methyleneisoindoline-1-ones from substituted 2-phenylethynyl benzamides, generated in situ from 2-(phenylcarbamoyl)phenyl-1- H -imidazole-1-sulfonates and corresponding alkyne by Cu-free Sonogashira cross-coupling–5-exo-dig-cyclization in aqueous medium under sonication. The compound could easily be purified by recrystallization from EtOAc without column chromatography.
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