Detection of Antibodies Against Synthetic Peptides Mimicking Ureases Fragments in Sera of Rheumatoid Arthritis Patients
2012
Rheumatoid arthritis (RA) is a chronic disease with an autoimmunological background. RA is mostly characterized
by systemic inflammation and injuries of synovial joints. There is a hypothesis that bacterial infections may be connected
with development of the disease. It has been suggested that molecular mimicry between bacterial and human antigens
may be one of possible mechanisms of RA development. One of potential antigens involved in this mechanism is
urease - enzyme with high structural conservatism, occurring in pathogenic and commensal bacteria. We found that the
level of antibodies against peptide mimicking urease "flap" region is significantly higher in sera from patients with rheumatoid
arthritis in comparison with volunteer blood donor sera. We also observed that antibodies present in RA sera may
bind not only specific peptide antigens but also peptides with a slightly different structure.
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