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IGF-II/IGF-IR相关信号通路与肝细胞癌靶向治疗
2011
胰岛素样生长因子（insulin-like growth factor,IGF）-Ⅱ/IGFⅡ-ⅠR相关信号通路与肝细胞癌（hepatocellular carcinoma,HCC）发生发展密切相关.IGF-Ⅱ活化可经IGF-ⅠR传递促有丝分裂信号,增加HCC变可能.近来研究显示靶向IGF-Ⅱ或IGF-ⅠR可明显抑制HCC细胞增殖.本文就IGF-Ⅱ和IGF-ⅠR信号通路在肝细胞癌变、转化过程中的作用及作为HCC基因治疗靶目标的研究进展进行了评述.
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