ENVIRONMENTAL CARCINOGENESIS IN MAN AND ANIMALS

A presentation is made of conclusive and suggestive evidence from the literature concerning an extension of the natural and man-made environmental cancer hazards from man and experimental animals to domesticated and wild animals. Observations on many wild and domesticated animals are reviewed in relation to exposure to certain groups or types of suspected carcinogens: (1) aromatic amino-, nitro-, and azo- compounds; (2) coal tar and derivatives; (3) petroleum and derivatives; (4) arsenicals; (5) radioactive chemicals; (6) uv radiation; (7) lead; (8) selenium; (9) chlorinated hydrocarbons and other pesticides and herbicides (aminotriazole, beta-propiolactone, carbamates). Considerable emphasis is given to the use of urethan. Also discussed are (a) goitrogenic chemicals; (b) dietary additives, contaminants and deficiencies; (c) smegma. The paper is supplemented with 6 appendices with much additional detail on specific compounds, nature of exposure and population groups involved.