CODA-RET reveals functional selectivity as a result of GPCR heteromerization.

Based on a BRET readout, dopamine D2 receptor agonist NPA is more potent at activating Gαi when the D2 receptor forms a heteromer with the related D1 receptor than if it forms D2 receptor homomers, suggesting that GPCR heteromerization can result in functional selectivity.