Observation of therapeutic efficacy and toxicity of Durogesic and OxyContin in radiotheraputic mucositis-induced pain

Objective To observe the clinical efficacy of Durogesic and OxyContin in relieving moderate or severe acute radiotheraputic mucositis-induced pain,improving the life quality and adverse drug reactions in patients with nasopharyngeal carcinoma.Method A total of 66 patients with nasopharyngeal carcinoma who severe radiotheraputic mucosi-tisinduced pain was complained during radiotherapy were randomly divided into two groups:34 patients (OxyContin group) were treated with OxyContin plus routine therapy,and 32 patients(Durogesic group) were treated with Durogesic.The pain-relieving efficacy were recorded every 3 hours.The score of life quality and the side effects were recorded every 24 hours.Results There was significant difference between the two groups in radiotheraputic mucositis-induced pain.Conclusion OxyContin is convenient in the control of radiotheraputic mucositis-induced pain because of its rapid action and easy adjustment. Key words: Durogesic; OxyContin; Radiotheraputic mucositis; Therapeutic effect; Side effects