Genomic organization and chromosomal localization of mouse coronin-1.

Actin-binding proteins cooperate to form the cytoskeletal matrix and affect the regulation of a variety of cytoskeletal properties such as cell morphology, motility, and cytokinesis (Sheterline and Sparrow 1994). Signal transduction pathways are also dependent upon the cytoskeletal framework. Coronin, first described in Dictyostelium discoideum as an actin-binding protein containing five WD domains, is involved in phagocytosis, cell motility, and mitosis (deHostos et al. 1991, 1993; Gerisch et al. 1993; Maniak et al. 1995). In Dictyostelium discoideum, coronin is located at the crown-shaped edges of amboid cells and is recruited to nascent leading edges from the cytoplasm during macropinocytosis and phagocytosis (Maniak et al. 1995; Gerisch et al. 1995; Hacker et al. 1997; Rauchenberger et al. 1997). Correspondence to: M.L. Thomas