Adult T cell large granular lymphocytic leukemia

Large granular lymphocyte (LGL) leukemia is a rare chronic lymphoproliferative disorder manifesting as leukemia in absence of any lymphadenopathy. This entity was first described in 1985 as a clonal disorder involving tissue invasion of marrow, spleen, and liver.1 Clinical presentation is dominated by recurrent infections associated with neutropenia, anemia, splenomegaly, and autoimmune diseases, particularly rheumatoid arthritis (RA).2 We report a case of T cell LGL leukemia in an old woman patient suffering from chronic anemia who was diagnosed and treated at our hospital.