Are Patients With Fibromyalgia in a Prothrombotic State

Objectives:The aim of this study was to investigate thrombosis-related parameters (blood coagulation parameters, platelet indices, red blood cell [RBC] count, and inflammatory markers) in patients with fibromyalgia (FM).Method:We carried out a case–control study with 35 women with FM and 12 age-matched healthy volunteers to analyze fibrinogen levels, prothrombin time, cephaline time, platelet count, platelet distribution width (PDW), mean platelet volume (MPV), RBC count, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio (PLR).Results:The results showed significantly increased fibrinogen levels (p < .05), platelet count (p < .05), PDW (p = .059), RBC count (p < .05), and PLR (p < .05) in women with FM versus the healthy volunteers. Prothrombin time (p < .05) and MPV (p < .05) were significantly lower in patients with FM than in the controls.Conclusions:Elevated platelet and RBC counts, PDW values, and fibrinogen levels as well as decreased prothrombin time are all indicative of a prothrombo...