Substituted amides, method of preparation and use as inhibitors of Btk

Compound of formula I: ** ** Formula and salts, solvates, chelates, noncovalent complexes, and pharmaceutically acceptable mixtures, wherein R1 is selected from: ** ** Formula and R2 is H or CH3; Z is selected from phenylene and pyridylidene, wherein pyridylidene phenylene and optionally substituted with one or more groups independently selected from CN, halo, hydroxy, optionally substituted C1-4alkyl, and C1-4alkoxy optionally substituted; ** formula is selected ** ** ** formula each of which is optionally substituted with one or two groups selected from hydroxy, cyano, halo, C1-4alkyl optionally substituted, and C1-4alkoxy optionally substituted; each R16 is independently selected from hydrogen, cyano, optionally substituted cycloalkyl, and C1-4 alkyl optionally substituted; R17, R18, R19, R21, R22, and R23 are independently selected from hydrogen and C1-4alkyl optionally substituted; each R20 is independently selected from hydrogen, hydroxy, cyano, halo, C1-4alkyl optionally substituted, and C1-4alkoxy optionally substituted; D is -NHR7; and R7 is selected from optionally substituted aryl and optionally substituted heteroaryl.