Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival

Paolo Giovanni Artini,Carla Tatone,Samantha Sperduti,Marco D'Aurora,Sara Franchi,G. Di Emidio,Rosanna Ciriminna,Marilena Vento,C. Di Pietro,Liborio Stuppia,Valentina Gatta

Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival

2017

Paolo Giovanni Artini
Carla Tatone
Samantha Sperduti
Marco D'Aurora
Sara Franchi
G. Di Emidio
Rosanna Ciriminna
Marilena Vento
C. Di Pietro
Liborio Stuppia
Valentina Gatta

STUDY QUESTION Is the phosphoinositol 1,3-kinase/protein kinase B (PI3K/AKT) pathway expression profile in cumulus cells (CCs) a potential marker of oocyte competence and predictive of pregnancy outcome?

Keywords:

Gene expression
PI3K/AKT/mTOR pathway
Internal medicine
Endocrinology
Cell biology
Protein kinase B
Akt/PKB signaling pathway
Downregulation and upregulation
Kinase
Signal transduction
Biology
Proto-Oncogene Proteins c-akt
Gene signature
AKT1
FOXO3
Andrology
FOXO4
Oocyte

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