Altered Pattern of Connectivity in Chagas Disease

: It has been proposed that natural autoreactivity plays a physiological role in the immune system by connecting all these clones (Id/anti-Id) and forming a dense and highly regulated network. In the present work, we analyzed the connectivity pattern in Chagas disease. Serum samples of 20 chronic chagasic cardiopathy (CCC) patients with dilated cardiopathy, 20 infected–asymptomatic subjects (IAS), and 20 healthy seronegative controls (H) were tested. Pattern of connectivity was distinguishable from that of healthy donor and those with CCC and IAS. This suggests that there are alterations in regulatory networks, inclusive being more evident in CCC patients than in IAS.