MP32-15 CIGARETTE SMOKING IS ASSOCIATED WITH ADVERSE PATHOLOGIC RESPONSE AND INCREASED DISEASE RECURRENCE AMONG PATIENTS WITH MUSCLE-INVASIVE BLADDER CANCER TREATED WITH CISPLATIN-BASED NEOADJUVANT CHEMOTHERAPY AND RADICAL CYSTECTOMY

INTRODUCTION AND OBJECTIVES:Smoking may be implicated in mechanism of resistance to cisplatin-based chemotherapy in bladder cancer and other solid malignancies. However, evidence suggesting a nicotine-induced resistance to cisplatin-based neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (MIBC) is scarce. We aimed to investigate the association between smoking status and pathological response to cisplatin-based NAC and survival outcomes in patients with MIBC treated with radical cystectomy (RC).METHODS:We reviewed 201 patients treated with NAC and RC for cT2-cT4N0M0 BC between 01/1999 and 01/2015. Smoking status was categorized as never smoker, former and current smoker. Pathological response to NAC was defined as: complete (ypT0N0), partial (ypTis/Ta/T1,N0) and no response (ypT2-4 or ypN+). Clinicopathologic characteristics were analysed according to smoking status. Logistic regression analyses tested the association between smoking status and pathologic response to NAC. Cox regression an...