FORMULATION AND EVALUATION OF GATIFLOXACIN TOPICAL SEMISOLID DOSAGE FORMS

The aim of this work is to formulate Gatifloxacin in different semisolid preparations including gels and emulgels of good rheological and release properties. All formulations contained 0.1w/w% Gatifloxacin(GF) concentration. Results showed that all semisolid formulations depicted acceptable physical properties, all gel and emulgel formulations followed non Newtonian, pseudoplastic flow,All formulations depicted thixotropic behavior with varying recovery rate.Polymers and formulations of lower viscosities achieved rapid recovery.Sodium carboxy methylcellulose(SCMC) gel(2w/w%)showed the most rapid recovery compared to other gel and emulgel formulations, Polymer concentration highly affected the degree of shear rate and shear stress. It was found that FEg7 depicted the highest drug release and permeation compared to the other emulgel formulations .Therefore it is the most suitable formulation for topical formulation.