The Phase-Transition Morphogenic Model for Oncogeny as a Genotoxic Homeostatic Dysfunction: Interdependence of Modeling, Advanced Measurements, and Numerical Simulation

dimensional reaction-diffusion equation with the biochemical-reaction term inspired by the well-known physical theory of nonstationary phase transitions of fluids. The model works with populations of cells. It describes both homeostasis and oncogeny (at any of its five main stages) in terms of the cell concentration and the conditions if a tumor is formed or not. It also clearly predicts an inherent connection between chronic inflammation and genotoxically activated oncogeny. The present work analyzes the corresponding interdependence of the above modeling, advanced measurement techniques, and numerical simulation. The focus of the analysis is on the critical concentration of the cells that separates oncogeny from homeostasis and which is affected by the efficiency of the autocrine signaling. We discuss in detail the prospects for the high-precision luminescence-based methods for measuring the oncogeniccell concentration by means of the approaches resulting from [4], [5]. A potential importance of optical effects in intercellular signaling is summarized. The work also explains the advantages of a cohesion of measurements and numerical simulation. In general, the work reports certain practice-relevant strategies, which are in line with the systems-biology integrated approach to oncogeny and cancer studies.