Mission CaMKIIγ: Shuttle Calmodulin from Membrane to Nucleus

Neuronal plasticity depends on plasma membrane Ca 2+ influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca 2+ initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca 2+ channels to the nucleus.