IL-2 Family of Cytokines in T Regulatory Cell Development and Homeostasis
2008
Introduction
Interleukin 2 (IL-2) induces an essential signal for T regulatory (Treg) cells. Without a functional IL-2R, only immature CD4+ Foxp3low CD25neg T cells develop, and these cells fail to suppress autoreactive T cells in the periphery.
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