New inhibitors based galectins 3-triazolyl-galactoside

2005 
A compound of general formula (I): Formula ** ** where pyranose ring configuration is D-galacto; X is selected from the group consisting of O and S; Y is selected from the group consisting of CH2, CO, SO2 and phenyl, or is a bond; R1 is selected from the group consisting of: a) glucose, mannose, galactose, N-acetylglucosamine, N-acetylgalactosamine, fucose, fructose, xylose, sialic acid, glucuronic acid, iduronic acid and galacturonic acid; b) D-galactose substituted C3- [1,2,3] triazol-1-yl; c) hydrogen, an alkyl group and an alkenyl group; and R2 is selected from the group consisting of hydrogen, an optionally substituted amino group, an alkyl group optionally substituted, an alkenyl group optionally substituted, an alkynyl group optionally substituted, an optionally substituted alkoxy group, an alkylamino group optionally substituted, an arylamino group optionally substituted, an aryloxy group optionally substituted, an optionally substituted aryl group and a heteroaryl group, wherein said optional substituents are halogen, alkyl, which in turn may be optionally substituted, alkoxy, nitro, sulfo, amino, hydroxy or carbonyl, wherein: the alkyl group is a straight or branched chain containing from 1 to 12 carbon atoms, or a cycle comprising from 3 to 12 carbon atoms; the alkenyl group is a group comprising from 2 to 12 carbon atoms and at least one double bond; the aryl group is a group comprising 4 to 18 carbon atoms such as a phenyl group or a naphthyl group; the alkoxy group is a group comprising from 1 to 12 carbon atoms; such as a methoxy group or an ethoxy group; the alkylamino group is a group comprising from 1 to 12 carbon atoms; the arylamino group is a group comprising from 4 to 12 carbon atoms, such as aniline, aniline carboxylated or halogenated aniline; the aryloxy group is a group comprising from 4 to 12 carbon atoms, such as phenol, halogenated phenol or carboxylated phenol; and the heteroaryl group is a group comprising 4 to 18 carbon atoms, wherein at least one ring atom is a heteroatom.
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