crush resistant designed to prevent accidental misuse tablets and diversion of illicit use

insoluble matrix tablets in water which can release one or more active ingredients in the body for prolonged periods in time and comprising at least one active ingredient that may experience a deviation of use with drug abusers purposes dispersed within a matrix of compression, being said matrix consisting of a mixture of microcrystalline cellulose and [polyvinyl acetate / polyvinylpyrrolidone (80:20)], characterized by: - ​​said active substance represents 10 to 50% by weight of the total tablet weight, - said matrix compression represents 50 to 98% by weight of the total weight of said tablet, advantageously 85 to 95%, - said mixture of microcrystalline cellulose and [polyvinyl acetate / polyvinylpyrrolidone (80:20)] represents 100%, advantageously 50 to 90% by weight of the total weight of the matrix, and obtained by applying the compression forces between 10 kN and 160 kN.