Relationship between serum IL- 6 and PCT with severity of acute pancreatitis

Objective To investigate the value of using proinflammatory cytokine interleukin- 6( IL- 6) and procalcitonin( PCT) to assess the severity and prognosis of acute pancreatitis( AP). Methods Chose 28 cases of severe acute pancreatitis( SAP) and 36 cases of mild acute pancreatitis( MAP) for the study group,the other 47 healthy subjects for the control group. We utilized enzyme- linked immunosorbent assay( ELISA) to detect the serum IL- 6 and PCT level, and analyzed the relationship between the two levels and the patients Ranson score,APACHE Ⅱ score,Bahhazar CT score,serum biochemical markers and prognosis respectively. Results In SAP group,MAP group and healthy control group respectively,the serum IL- 6 levels were( 531. 37 ± 168. 67) pg / ml,( 261. 32 ± 178. 55) pg / ml,( 15. 31 ± 3. 15) pg / ml,the differences among the three groups were statistically significant( P 0. 01),and the serum PCT levels were( 4. 22 ±2. 84) ng/ml,( 0. 45 ± 0. 33) ng/ml,( 0. 12 ± 0. 11) ng/ml,the differences were also statistically significant( P 0. 05). Serum levels of IL-6 and PCT were positively correlated with Ranson score,APACHEⅡ score,Balthazar CT score. Conclusion The serum IL- 6 and PCT levels were significantly associated with the severity and complications of acute pancreatitis.