HPV-transgenic mouse models: Tools for studying the cancer-associated immune response

Abstract For decades, research on the pathogenesis of papillomavirus-induced lesions, particularly of human papillomavirus (HPV) has relied on the use of animal models. Among these, HPV-transgenic mice are some of the most frequently employed. After some initial unsuccessful attempts, researchers have succeeded in targeting the expression of one or more HPV-16 oncogenes to squamous epithelia, closely mimicking the lesions observed in cancer patients. The present review describes the relevance and usefulness of these animal models in understanding the tumour-associated immune response and developing new preventive and therapeutic strategies for HPV-associated cancers. In particular, this review details the importance of transgenic mice for dissecting and modulating relevant aspects of the tumour-associated immune response. Other animal models for studying papillomaviral diseases are briefly mentioned, along with their respective advantages and limitations. HPV-transgenic mouse strains remain reliable, versatile and commodious, even if perhaps underestimated, animal models for studying HPV-induced multi-step carcinogenesis.