Cortical phase locking to accelerated speech in blind and sighted listeners prior to and after training

Abstract Cross-correlation of magnetoencephalography (MEG) with time courses derived from the speech signal has shown differences in phase-locking between blind subjects able to comprehend accelerated speech and sighted controls. The present training study contributes to disentangle the effects of blindness and training. Both subject groups (baseline: n = 16 blind, 13 sighted; trained: 10 blind, 3 sighted) were able to enhance speech comprehension up to ca. 18 syllables per second. MEG responses phase-locked to syllable onsets were captured in five pre-defined source locations comprising left and right auditory cortex (A1), right visual cortex (V1), left inferior frontal gyrus (IFG) and left pre-supplementary motor area. Phase locking in A1 was consistently increased while V1 showed opposite training effects in blind and sighted subjects. Also the IFG showed some group differences indicating enhanced top-down strategies in sighted subjects while blind subjects may have a more fine-grained bottom-up resolution for accelerated speech.