The preparation of α-chitin nanowhiskers-poly (vinyl alcohol) hydrogels for drug release

Abstract A series of highly porous and biocompatible poly (vinyl alcohol) (PVA) hydrogels containing partially deacetylated α-chitin nanowhiskers (ChWs) were fabricated by the double-cross-link (DC) with glutaraldehyde (GA) and repeating freeze-thawing cycle. Then these hydrogels were used as carrier for bovine serum albumin (BSA), which served as the model drug. The nanowhiskers worked effectively to raise the mechanical property of the PVA/ChWs hydrogels. This property increased significantly from 1.55 to 26.59 MPa with the increase of the ratio of ChWs to PVA from 0% to 40%. Additionally, the morphological properties of the gel matrix were comprehensively investigated. The results showed that the novel ChWs/PVA hydrogels were facilely constructed from sequential chemical cross-linking and physical cross-linking with GA. The hydrogel with the ChWs to PVA weight ratios of 40% achieved the highest equilibrium swelling ratio, and could release more than 80% of the BSA from its gel matrix within 75 h.