The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Jafar Sharif,Masahiro Muto,Shin-ichiro Takebayashi,Isao Suetake,Akihiro Iwamatsu,Takaho A. Endo,Jun Shinga,Yoko Mizutani-Koseki,Tetsuro Toyoda,Kunihiro Okamura,Shoji Tajima,Kohzoh Mitsuya,Masaki Okano,Haruhiko Koseki

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

2007

Jafar Sharif
Masahiro Muto
Shin-ichiro Takebayashi
Isao Suetake
Akihiro Iwamatsu
Takaho A. Endo
Jun Shinga
Yoko Mizutani-Koseki
Tetsuro Toyoda
Kunihiro Okamura
Shoji Tajima
Kohzoh Mitsuya
Masaki Okano
Haruhiko Koseki

Np95 recruits the DNA methyltransferase Dnmt1 to hemi-methylated DNA at replicating heterochromatic regions. It is required in vivo to maintain DNA methylation and repress transcription of retrotransposons and imprinted genes

Keywords:

Human genome
RNA-Directed DNA Methylation
DNA methyltransferase
DNA methylation
Epigenetics of physical exercise
Histone methylation
Genetics
Epigenomics
Biology
Methylated DNA immunoprecipitation
Epigenetics

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

959

Citations