Mixed hyaluronic-acid gel and preparation method thereof

The invention provides mixed hyaluronic-acid gel and a preparation method thereof, wherein the method comprises the following steps of making sodium hyaluronate react with a cross-linking agent in a condition that a pH (potential of Hydrogen) value is 9 to 13, so as to obtain cross-linked sodium-hyaluronate gel; making polynucleotide react with the cross-linking agent in a condition that a pH value is 2 to 5, so as to obtain cross-linked nucleotide gel; mixing the cross-linked sodium-hyaluronate gel with the cross-linked nucleotide gel, then making an obtained mixture react with the cross-linking agent once again, and finally preparing to obtain the mixed hyaluronic-acid gel. According to the mixed hyaluronic-acid gel and the preparation method thereof, through two cross linking reactions, the problems that a hyaluronic acid type filling agent or gel in the prior art cannot be used for not only guaranteeing the in-vivo persistence time of hyaluronic acid, but also enabling a cell growth factor to effectively promote the growth of the self collagenous fiber of an organism are solved.