Investigation of the Radioprotective Efficiency of Condensation Products of Thiol-Containing Hydrazides with Mono- and Disaccharides

In experiments in mice, the radioprotective efficacy of sugar-containing compounds was studied based on the condensation products of thioglycolic (TGH) and thiosalicylic (TSH) hydrazides with a series of natural aldoses: the monosaccharides D-glucose (Glс) and D-galactose (Gal) and the disaccharides D‑lactose (Lac) and D-maltose (Mal). It was shown that the use of Glc-TGH and Mal-TSH preparations increases the survival rate of deadly irradiated animals by 25% when administered 1 h before irradiation and by 40% when administered 24 h before irradiation. It is assumed that the leading role in the radioprotective activity of the drugs is played by the protection of the hematopoietic stem cells of the test animals.