Antibacterial activity of Sonoran propolis and some of its constituents against clinically significant Vibrio species.

Abstract The aim of the present study was to evaluate the anti-Vibrio activity of propolis collected from three different areas of the Sonoran Desert in northwestern, Mexico [Pueblo de Alamos (PAP), Ures (UP), and Caborca (CP)]. The anti-Vibrio spp. activity of Sonoran propolis was determined by the broth microdilution method. UP propolis showed the highest antibacterial activity [minimal inhibitory concentration (MIC50) CP>PAP). UP propolis significantly inhibited the growth of Vibrio cholerae O1 serotype Inaba (MIC50<50 μg mL−1), V. cholerae non-O1 (MIC50<50 μg mL−1), V. vulnificus (MIC50<50 μg mL−1), and V. cholerae O1 serotype Ogawa (MIC50 100 μg mL−1), in a concentration-dependent manner. The UP propolis constituents, galangin and caffeic acid phenethyl ester (CAPE), exhibited a potent growth inhibitory activity (MIC50 0.05–0.1 mmol l−1) against V. cholerae strains (non-O1 and serotype Ogawa). The strong anti-Vibrio activity of Sonoran propolis and some of its chem...