Effects of preoperative carbohydrate loading on the changes in serum tumor necrosis factor receptors 1 and 2 and insulin resistance in patients of colon carcinoma

Objective To investigate the effects of preoperative carbohydrate loading and new fasting protocol treatment on the postoperative changes in serum tumor necrosis factor receptor1 ( sTNFR1 ), sTNFR2,and insulin resistance (IR) in patients of colon carcinoma.Methods 51 patients of colon carcinoma were randomly divided into 2 groups:carbohydrate-rich beverage group ( n = 24),undergoing fasting 6 h before operation and water deprivation 2 h before operation,receiving carbohydrate-rich beverage 3 h before operation and fluid therapy with glucose post-operatively,and placebo group ( n = 27) undergoing routine fasting and water deprivation pre-operatively.Peripheral blood samples were collected before, during,and 1,4,and 7 d after operation.ELISA was used to detect the sTNFR1 and sTNFR2 of preoperative,1,4,7day Insulin sensitivity index (S1) was calculated.Results The S1 levels at different post-operational time points of the treatment group were not significantly different from those preoperatively (all P > 0.05 ),while the S1 levels of the control group decreased significantly compared to those before operation( all P 0.05 ).The time to first flatus and days staying in hospital of the treatment group were (77 ± 15) hours and (11 ± 1.2 ) gays respectively,both significantly shorter than those of the control group [ (86 ± 13) hours and ( 15.1 ± 3.8) days respectively,both P < 0.05 ].Conclusion Preoperative carbohydrate loading and new fasting protocol reduce the degree and course of IR,increase the sTNFR1 level,and decrease the sTNFR2 level and days of staying in hospital. Key words: Colonic neoplasms;  Receptors,tumor necrosis factor;  Insulin resistance;  Preoperative carbohydrate loading