Biodegradable Electrospun Fibers Containing the Compound Antihypertensive Drugs

In this study, the biodegradable composite fiber contained different ratios of the compound antihypertensive drugs were electrospun.The morphology, chemical components, heat stability of the composite fibers were investigated.The results showed the diameters of the composite fibers decreased and their distributions tended to be much evener with the increase of the compound antihypertensive drugs content. Fourier Transform Infrared (FT-IR) showed the chemical components of the compound antihypertensive drugs had not changed when it was electrospun into the composite fibers. DSC results showed that the drugs lost their intrinsic crystallization and existed in amorphous state in the composite fibers and the heat stability of the composite were better than the pure drug.