Psychotropic activity and antimonoamine oxidase action of 1-thiolactim ethers of 3-carboline

1,5,6-Trimethyl-2-hydroxymethylimidazo[4,5-b]pyrazine (IX). To a solution of VIII (1.03 g) in methanol (9 ml) was added 0.7% methanolic sodium hydroxide solution (0.6 ml) and the mixture left for 30 min at 20-22 ~ The methanol was removed in vacuum, and the residue recrystallized from a mixture of ethyl acetate-methanol. Compound IX (0.77 g: 91.7%) was obtained having mp 178-179 ~ . Found, %: C 56.2;H 6.4; N 29.1. CgHI2N40. Calculated, %: C 56.3; H 6.3; N 29.1.