Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

Zhenming Jin,Yao Zhao,Yuan Sun,Bing Zhang,Haofeng Wang,Yan Wu,Yan Zhu,Chen Zhu,Tianyu Hu,Xiaoyu Du,Yinkai Duan,Jing Yu,Xiaobao Yang,Xiuna Yang,Kailin Yang,Xiang Liu,Luke W. Guddat,Gengfu Xiao,Leike Zhang,Haitao Yang,Zihe Rao

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

2020

A crystal structure of SARS-CoV-2 with inhibitor carmofur reveals the mechanism of action of this compound and opens the way to develop more potent drugs.

Keywords:

Coronavirus disease 2019
Biochemistry
antineoplastic drug
Carmofur
severe acute respiratory syndrome coronavirus 2
Mechanism of action
Protease
2019 20 coronavirus outbreak
Biology
Viral replication
Vero cell
Lead compound
Viral protein
Covalent bond
Fatty acid

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

193

Citations