Effect of Smallanthus sonchifolius (Ss) leaf extract on glucose metabolism in mice fed a high fructose diet (HF)

A high fructose diet (HF) might play a role in the onset of metabolic disorders and excess weight gain. Usually, the consumption of this diet can induce insulin resistance and increase intrahepatocellular lipids. Smallanthus sonchifolius (Ss) leaf have been studied for their hypoglycemic activity in diabetes type I models. It seems that effect could be related with the high content of phenolic compounds and their in vitro antioxidant activity. For most of the studies using Ss, the leaf extract was obtained using classic techniques of extraction such as maceration followed by organic extraction and evaporation. During this manipulation process, several active substances can be lost. In this study, our Ss extract was obtained using a spray drying encapsulation technique with the intuit to prevent as much as possible the bioactive loss. The aim of this work was evaluate the Ss extract capacity to prevent disorders in glucose metabolism (in a diabetes type II model). Male mice (n=6/group) were fed with a cont...