Plasma-Activated Solution in Cancer Treatment

Cold plasma-activated solution (PAS), particularly the cold plasma-activated medium (PAM), is a type of chemotherapy used in the cold plasma-based cancer treatment. Compared with the direct cold plasma treatment, PAM can be stored for a long time and can then be used without dependence on cold plasma sources or devices. Many in vitro and in vivo experiments have demonstrated anti-tumor effects of PAM against a variety of cancer cells. PAM contains a variety of reactive oxygen species (ROS), reactive nitrogen species (RNS), other cold plasma-activated species, and the generated compounds. These species either interact with the cellular membrane or the intracellular function to activate signal pathways and the expression of many genes. Several important signaling pathways are affected by PAM. The effectiveness of PAM has been demonstrated in animal studies using peritoneal metastasis model mice.