Synthesis of o - and m -Boronophenylalanine

p-Boronophenylalanine (p-BPA) has been used for Boron Neutron Capture Therapy (BNCT). The synthetic route to p-BPA was developed by Snyder et al. 1. o- and m-Boronophenylalanine (o- and m-BPA) are the isomers of p-BPA, and they may be incorporated into melanoma cells such as p-BPA and used for BNCT. Even if this incorporation dose not happen, this will give us informations about the relationship between structure and incorporation. Therefore, we have developed a way of synthesizing o-BPA and m-BPA.