FRI0409 Smoking and SjÖGren's Syndrome Are Predictors of Autoimmune Thyroid Disease in Systemic Lupus Erythematosus

Background Autoimmune thyroid disease (AITD) has been described as the most prevalent autoimmune disease (AD) as well as being associated with other organ-specific and non-organ specific ADs. Objectives To determine the prevalence, risk factors and the impact of AITD in patients with systemic lupus erythematosus (SLE). Methods A total of 376 patients with SLE were systematically assessed for the presence of: 1) confirmed AITD (i.e., TPOAb/TgAb and hypothyroidism), 2) positive TPOAb/TgAb without hypothyroidism, 3) clinical hypothyroidism without TPOAb/TgAb and 4) SLE patients with neither. Autoantibodies including TPOAb and TgAb were performed by ELISA. Comparisons between groups 1 and 4 were done by multivariate analysis and regression tree (CART) predictive model. Results The prevalence of confirmed AITD was 12%. The frequency of positive thyroid antibodies without hypothyroidism and clinical hypothyroidism without TPOAb/TgAb were 11% and 13.5%, respectively. SLE patients with neither were 40%. The duration of the disease was similar in groups 1 and 4. Patients with confirmed AITD were significantly older and had later age at onset of the disease. AITD was associated with multiple autoimmune syndrome (MAS), carrying Sjogren9s Syndrome and with ever smoking, regardless of gender and duration of the disease (Table 1). These variables were also found as the main predictors for AITD in SLE. Conclusions Identified risk factors will assist clinicians in the search for AITD and encourage smoke-free policies in patients with SLE. AITD does not affect the severity of SLE. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.4574