Effect of local revascularization of choroid on ocular tissues and lipid peroxidation in experimental atherosclerotic chorioretinopathy

: Lipid composition and lipid peroxidation in ocular tissues were assessed in 42 rabbits with hypercholesterolemia. The levels of nonesterified cholesterol, diacylglycerides, nonesterified fatty acids, and of malonic dialdehyde were increased and the content of endogenous antioxidants decreased in animals with experimental atherosclerotic chorioretinopathy. Surgery (local revascularization of the vascular coating with two flaps) resulted in improvement of ocular biochemistry and microcirculation in the posterior segments of the eye and in recovery of the functional intactness of the retina and choroid.