Úlceras crónicas: modelo de integración entre patología vascular, inmunológica e infecciosa

Se conocen como ulceras cronicas aquellas heridas que no cicatrizan en un periodo largo de tiempo, caracterizadas por presentar un area necrotica en el sitio de lesion con un centro purulento y sanguinolento, causando dolor en la persona que la padece. Causan una respuesta inflamatoria cronica produciendo un dano mayor en el tejido y evitando la cicatrizacion del mismo. Planteamos un modelo que relaciona la gravedad de las ulceras vasculares (venosas y/o arteriales), infecciosas (Mycobacterium ulcerans) y las asociadas a alteraciones inmunologicas (desbalance entre el perfil de citocinas proinflamatorias y antiinflamatorias), lo que conlleva a un proceso de inflamacion cronica evitando la cicatrizacion del tejido ulcerado. Chronic ulcers: an integration model of vascular, immunological & infectious pathologies Abstract Chronic ulcers are those that do not heal during a long period of time. They are characterized by necrosis of the injured tissue with a purulent center and bleeding, being a painful condition. They are caused by an exaggerated inflammatory response producing major damage in the tissue and interfering with cicatrization. This model shows the relationship between the effects caused by vascular problems (venous and/or arterial), those caused by infectious agents (Mycobacterium ulcerans) and the immunological alterations that happen as a consequence of the evolution of the ulcer (unbalanced profile of proinflamatory and anti-inflammatory citocines), leading to a chronic process of inflammation retarding cicatrization of the ulcered tissue.