Control of apoptosis by using small molecule regulators of Bcl-2 family proteins

The potent biological activity of CPM-1285 suggests that it may represent a promising lead for the development of new anticancer agents. The cell permeable Bcl-2 inhibitor can also be used as a chemical probe to study the in vivo mechanism and signaling pathway of the Bcl-2 family. Unlike other peptides that are active only in vitro or in the cell-free system, the cell-permeable peptide approach described here provides a new tool to analyze the function of the Bcl-2 family in living cells and animals.