Effect of Alpinia officinarum Hance alcohol extracts on primary dysmenorrheal

Abstract Objective To study the effect of Alpinia officinarum Hance ( A. officinarum ) 80% alcohol extract on the primary dysmenorrhea. Methods A. officinarum 80% alcohol extract were enriched by macroporous adsorption resins. Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A. officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F 2α (PGF 2α ), prostaglandin E 2 (PGE 2 ) and Ca 2+ in the uterus were observed in oxytocin-induced female mice. Results The writhing frequency of primary dysmenorrhea mice was significantly decreased after treatment of A. officinarum 80% alcohol extract and the level of PGF 2α , PGE 2 and Ca 2+ in mice uterus was significantly decreased ( P P A. officinarum 80% alcohol extract compared with that of model group. Conclusions These findings suggest that A. Officinarum 80% alcohol extract can significantly relieve primary dysmenorrhea.