Effect of Follicular Activin a and Granulocyte Macrophage-Colony Stimulating Factor on the Prediction of Pregnancy Rate Following Intracytoplasmic Sperm Injection in Women with PCOS

Polycystic ovary syndrome (PCOS) is a reproductive endocrinopathy of obscure etiology, and it is regarded as a complicated disorder, Activin A is one member of the transform growth factor-superfamily (TGF), which has a role in stimulating the synthesis, and secretion of FSH. The Granulocyte macrophage-colony-stimulating factor (GM-CSF), is act as important mediator for inter-cellular communications, and has effects in the process of the implantation. The goal of present study is to elucidate the effects of both activin A hormone and GM-CSF on implantation and successful pregnancy of embryos developed after ICSI.