The Influence of β-Adrenoceptor Blocking Agents on Plasma Thyroxine and Triiodothyronine
1977
The effect of the β-adrenoceptor blocking agent propranolol on plasma levels of thyroxine and triiodothyronine was studied in eleven hyperthyroid patients and in six hypothyroid patients on L-thyroxine substitution therapy. In all patients a decrease in plasma-triiodothyronine was found. The per cent decrease of plasma-triiodothyronine was the same in both groups. Plasma levels of thyroxine and thyrotropin increased in the hypothyroid patients, but remained constant in the hyperthyroid subjects. The decrease in plasma-triiodothyronine during propranolol medication ismost likely caused by an inhibition of the peripheral conversion of thyroxine into triiodothyronine.
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