The effect of methotrexate on the development of synapses in the neonatal rat hippocampus.
1989
The density of E-PTA-stained synaptic junctions per unit area was significantly reduced by MTX exposure either during day 1-5 or 6-10 postpartum. It was suggested that administering MTX during the critical period affected the development of synapses in the developing rat brain
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